OBJECTIVE: To prepare traditional Chinese medicine formula Qiqi pellets by extrusion-spheronization and study the optimal formulation and process.
METHOD: Qiqi pellets were prepared by a new style extrusion-spheronization equipment, the optimal formulation and process was obtained by the studies of influenitial factors and L9 (3(4)) orthogonal design, the micromeritic properties and product yield of pellets were determined.
RESULT: The formula Qiqi pellets prepared by extrusion-spheronization were all spheral with smooth surface; the product yield was high.
CONCLUSION: extrusion-spheronization was suitable to produce Chinese Herbal Medicine pellets. The preparation process was simple and feasible; The quality of the prepared pellets was excellent. It was worth further study.